PW03-010 - MHC complexity in Behçet's disease

نویسندگان

  • MJ Ombrello
  • Y Kirino
  • P de Bakker
  • F Cosan
  • DL Kastner
  • A Gul
  • EF Remmers
چکیده

Introduction Family studies support a genetic contribution to Behçet’s disease (BD), with a sibling recurrence-risk ratio of 1152. The class I MHC molecule, HLA-B*51 (B*51), is the strongest known genetic risk factor for BD, however the gene immediately centromeric to HLA-B, MICA, has also been implicated in BD. Because of strong linkage disequilibrium (LD) between HLA-B and MICA, their respective contributions to BD susceptibility have been debated. A recent report has proposed that B*51 is not a BD susceptibility allele, and several studies have identified B*51independent association signals within the MHC.

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عنوان ژورنال:

دوره 11  شماره 

صفحات  -

تاریخ انتشار 2013